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Biosciences at Sheffield Apply for this course You are viewing this course for entry. Get the best start for a career in industrial or academic research. This course covers human, plant and microbial genetics, genomics and molecular biology.
The first three years of your course will have the same structure as the BSc, with the fourth year devoted to a major research project working in industry or in an academic lab with our world-leading academics. Whether you choose to focus solely on genetics, or study a range of topics across the molecular biosciences and beyond, your personal tutor will assist you in tailoring your degree to your interests and career goals. If you want to study this course but don't meet the entry requirements our Biosciences with a Foundation Year could be for you.
After successfully completing the one year programme, you'll progress onto the first year of one of our bioscience degrees. Advanced accreditation by the Royal Society of Biology, which shows employers that you've developed the practical skills and scientific knowledge that they're looking for. The modules listed below are examples from the last academic year.
There may be some changes before you start your course. For the very latest module information, check with the department directly. In your first year, you'll spend six hours in the lab each week learning the practical skills and knowledge that every bioscientist needs, including how to establish bacterial cultures, assess bioenergetics and perform gene cloning. Analysis classes will equip you with the skills you'll use outside the lab, from interacting with your data to interpreting your findings.
Your lectures will give you a broad understanding of the molecular biosciences, allowing you to explore what you're most interested in. Core modules:. This module provides a broad introduction to Biochemistry and examines the molecules that carry out and control all the chemical reactions in biological cells. The basic chemical concepts underlying the structures, functions and mechanisms of action of biomolecules.
This module considers the fundamental processes at the heart of all life on this planet. Students will learn about the basic molecular processes that enable cells to store and use genetic information to make proteins, as well as the mechanisms that allow cell growth, division, and ultimately cell death. Learning materials will be delivered through a combination of lectures, videos, practical classes and independent study.
This course is an introduction to evolution as the central unifying theme of modern biology. Students will examine evolutionary patterns from the geological past to the present, and investigate evolutionary mechanisms of selection, adaptation and the origin of species. They will be introduced to the approaches used to study evolution including classical population and quantitative genetics, phylogenetic trees, and the fossil record.
Students will learn through lectures, videos, practical sessions, quizzes, and independent study. This course is an introduction to the principles of genetics. Students will explore the genetics of pro- and eukaryotes by studying the mechanisms of gene transmission, genetic exchange, mutations and gene mapping. Additional topics are the genetic basis of diseases, prenatal diagnosis, genetic counselling, gene therapy and genetic basis of antibiotic resistance in bacteria.
Students will learn through lectures and videos and independent study. The Skills for Biology module introduces students to the fundamentals of scientific practice: lab practical skills, experimental de, information technology, data visualisation and analysis, writing and presentation skills, skills reflection, professionalism and career development. Optional modules:. A student will select approved modules from the School of Biosciences to the value of 20 credits.
You'll continue to take analysis classes to develop your data handling skills further and you can choose to study modules that allow you to work in teams to come up with pioneering science enterprise ideas to launch a virtual business. This module provides detailed knowledge in key areas of practical molecular bioscience, emphasising the integration of the disciplines of biochemistry, microbiology and genetics.
An important aim of the module is to provide experience in the preparation of written laboratory reports, and in the correct interpretation and representation of biological data. Laboratory, computer and data analysis sessions build on the skills gained during first year and allow students to develop a high level of technical competence and theoretical understanding. Tutorial-based support is also provided for the enhancement of transferable skills, such as the preparation and delivery of oral and written presentations.
This module aims to furnish students with a working knowledge of the structures and functions of proteins and nucleic acids, in order that they gain an appreciation of the crucial relationship between structure and function. Both cytosolic globular and membrane proteins will be considered, as well as an introduction to nucleic acid structure. The module also explains the basic principles of how energy is made available transduced for essential biological functions, such as ATP synthesis and solute and protein transport.
To achieve this understanding, the nature of biological membranes and the energy transducing proteins associated with those membranes are considered, and the principles of chemiosmosis, light absorption and biological redox reactions are discussed. Finally the module provides an understanding of the general principles underlying the biosynthesis of complex biomolecules from simpler precursors, and the control of these processes, with particular relevance to biotechnology.
This module aims to provide the student with a clear understanding of how genomes are organised within cells and how the expression of specific genes can be regulated. One part of the module addresses experimental approaches to address the function of specific genes and how genetic information is expressed in a regulated manner. Both classical and molecular genetics techniques to study gene function will be described.
DNA repair and recombination mechanisms will be addressed, along with the use of reporter gene fusions. The regulation of gene expression at the molecular level will be explored through the consideration of post- transcriptional control mechanisms and intercellular alling pathways. The other part of the module discusses the structural features of chromosomes and how they contribute to the maintenance and evolution of the genome; the development of sequencing techniques and their application to genome sequencing projects; the use of scoring systems to determine related DNA sequences and the application of sequencing technologies to measure gene expression, identify protein binding sites within DNA, analyse long range nucleic acid interactions within genomes and study DNA methylation patterns.
This module builds upon the introduction to genetics provided by MBB Genetics. A range of eukaryotic genetic systems will be considered, including humans and a of model organisms, ranging from yeasts to Drosophila melanogaster, Caenorhabditis elegans, Arabidopsis thaliana and Mus musculus. Topics to be covered include methods for isolating and genetically analysing mutants with specific phenotypes, extranuclear inheritance, developmental genetics, quantitative inheritance, population genetics and evolutionary genetics.
A collaborative group work exercise will give students opportunities to apply concepts introduced in the module to the analysis of genetic data, planning of experiments and the creation of a t report. This module provides an advanced treatment of the biochemical topics introduced in earlier modules, to provide a deep understanding of the underlying chemical principles and molecular interactions governing life in cells. Topics covered include reaction and ligand binding kinetics, enzyme catalysis and chemical mechanism, protein structure and function, small molecule drug development and methods in which these processes are studied experimentally.
This module builds upon the microbiological topics introduced in earlier modules, including aspects of bacterial growth and gene regulation, microbial biodiversity and cellular differentiation, biotechnology, the mechanisms used by pathogenic bacteria to subvert and fool the host's defences, the use of vaccines and antimicrobial agents in controlling and treating diseases caused by pathogens, the problems associated with newly-emerging pathogens and the role that resistance to antimicrobial agents is playing in the re-emergence of certain diseases.
In your third year, you'll complete an extended research project alongside your chosen specialist modules. This will reflect an area of molecular bioscience that interests you. Depending on your interests and career goals, you can choose a project from: experimental science, clinical diagnostics, industrial biotechnology, molecular systems and computing, science communication or education and outreach. This module is a research project in the molecular biosciences that allows students to apply their core subject knowledge to develop key skills in an Sheffield man needed for dd type of relationship related to their career aspirations.
Students have the opportunity to de, plan, and undertake an investigation, either within the Department or externally. Projects choices include laboratory-based research; biotechnology; computational biology and bioinformatics; science communication; science teaching in a local school; and clinical diagnostics.
All projects are undertaken under the supervision of a member of academic staff; most placements are within the Department, but a small proportion of students undertake projects in other locations, such as the Medical School. Students will develop skills in the collation, interpretation, presentation, and communication of data and ideas. Students will submit their work in the form of a formal written report and present their research to the department during a showcase poster event.
In this module students are required to write a literature review on a topic chosen from a wide range suggested by members of staff. Students will develop a range of transferrable key skills associated with searching for, analysing and critically evaluating information from the literature, together with presentation skills in writing Sheffield man needed for dd type of relationship presenting their review.
The module aims to develop interpretative skills by the study of deductive questions drawn from the broad area of molecular genetics and cell biology. Students will gain experience in the analysis, interpretation and evaluation of published data of different types through a directed programme of reading, discussion and question answering. The module also contains an element that develops the skills required by the students to write on a broad topic drawn from across all their areas of study. Multicellular organisms develop from a single zygote and in the case of humans, culminates in a mature human body consisting of over a trillion cells and around different cell types.
This module will examine the developmental mechanisms and genes that regulate pattern formation and cell identity in multicellular Sheffield man needed for dd type of relationship. We will focus on the role of key genes in the regulation of different developmental processes and the mechanisms that determine the correct temporal and spatial expression of these genes. We will illustrate these principles using examples from model organisms such as Mus Musculus, Caenorhabditis elegans, Drosophila melanogaster and Arabidopsis thaliana.
These systems have ificantly informed our understanding of human disease but also demonstrate the different mechanisms through which cell fate and complexity are controlled. The module examines in detail the mechanisms that maintain genome integrity and generate genetic variation, both of which are essential to eukaryotic life. The lectures illustrate how preventing and creating changes in DNA make use of the same biochemical machinery. The main emphasis is on eukaryotes, reference is made to prokaryotes mainly as an aid to understanding the importance of conserved processes.
Mechanisms studied in detail include single-strand break repair, protein-linked DNA break repair, homologous and non-homologous recombination, avoidance of replication errors, mismatch repair, excision repair and mutagenesis. Throughout the module experimental detail is included to illustrate how conclusions on gene function and interactions have been determined. A top-down approach to biology, simultaneously investigating the structure and function of the entire genome and its products, both contrasts with and complements the traditional gene-by-gene approach, allowing us a birds-eye view.
In this module, we cover how genome sequencing can be used to understand the structure of human populations, profile microbial diversity and to trace the origins of disease outbreaks. We then discuss how methods such as RNA-seq, ChIP-seq and 4C can be used to investigate the genome-wide transcriptional profile, the chromatin landscape and the three-dimensional structure of the genome.
Finally we describe the use of technologies such as mass spectrometry to investigate the complete proteome of a cell. The module builds on the material from the level 2 module Genes, Genomes and Chromosomes, to illustrate how cutting-edge genomic and proteomic methods can be used address fundamental biological questions. This module will provide students with an understanding of how genomics has shaped our understanding of the evolution of modern humans.
This will be achieved through lectures, independent reading and a computational biology practical. Topics covered will include: the evolution of modern humans; the history of how humans colonised the world; how the Neanderthal genome has revealed hybridisation between Homo sapiens and Neanderthal man; how human genomes can tell us about the history and causes of modern genetic disorders; how our genomes reveal past episodes of selection; and how life history theory is used to study natural selection and evolution in pre-industrial humans.
This module will address some of the processes underlying human fertility: that is, hormonal regulation of the reproductive systems, gametogenesis and fertilisation. The module will then consider methods of contraception, reasons for infertility, and issues relating to the assisted reproductive technologies.
Finally, the importance of genetic imprinting will be discussed, together with a consideration of the impact of failures in imprinting. This module considers the application of biotechnology to plants, for both agricultural and research uses. It covers the production of transgenic plants and how this technology has resulted in genetically engineered crop plants that show novel traits or produce novel products. It also covers traditional methods of plant breeding for the development of novel crops without the use of genetic engineering.
The release of genetically engineered crops has and is having a major impact on society, raising issues of ethical, economic and ecological importance. An appreciation of these issues will be developed. This module will address the ways in which genetic factors influence our lifetime health. The module will focus on the methodology used to identify genetic factors involved in human genetic disease; that is, next generation sequencing, diagnostic PCR, karyotype analysis, fluorescence in-situ hybridisation FISH and microarray, and how genetic abnormalities result in disease.
The rapid advance in the understanding genetic basis of disease has led to the importance of genetic diagnostic testing in healthcare. The scientific tests used in this industry and the real-life patient cases will be addressed in this module. This module will analyse the vital roles that RNA plays in the life of a cell and how RNA is increasingly used as a tool to understand biology. These include transcription, RNA splicing, RNA stability, RNA export and translation and how all these processes are coupled in the cell to ensure efficient, quality-controlled gene expression.
The module aims to present the latest innovations and discoveries in the RNA world and their application. In your fourth year, the majority of your time will be devoted to a major research project. You can choose between spending a year in industry and completing your project at a company such as AstraZeneca, GSK or Unilever, or undertaking projects in one of our world-leading research labs within the department or the University of Sheffield Medical School.
This unit builds upon the skills in literature searching and interpretation developed in the Library Project and Data Handling units at level 3. It will result in the production of a literature review appropriate for inclusion in a postgraduate thesis.
The exact nature and scope of the literature review will be determined by discussion between the student and the supervisor, with additional input from the industrial supervisor for those students taking MBB Assessment will be on the basis of the literature review. This module will develop the ability of students to acquire information through the medium of research seminars and published scientific papers.
Students will attend Departmental research seminars and Sheffield man needed for dd type of relationship the publication of new scientific papers relevant to their research area. They will also attend a journal club, in which they will present a recently published research paper and summarise the presentations of other students. Assessment of the unit will be on the basis of the journal club presentation and a series of short reports on research seminars, journal club presentations and newly published scientific papers. This unit provides an opportunity to revise and update knowledge of technologies used routinely in biological research and introduces some advanced methods, with particular emphasis on raising awareness of the opportunities afforded by complementary technologies.
The course engages students with aspects of immunology, molecular biology and genetics, functional genomics, protein expression, statistics and bioinformatics. Diverse teaching formats, including formal lectures, guided small group work, discussion groups and student presentations are used to deliver content. This module provides an extended period of laboratory work, with training in experimental techniques, record keeping and writing up. Projects are supervised by a member of staff and related to ongoing research projects within the Sheffield man needed for dd type of relationship, although a proportion of students undertake projects in other locations such as hospitals and the Medical School.
This unit is deed to provide students with experience of undertaking investigations independently on a specific research topic, so that they can develop a research oriented approach, and gain experience of lab work in preparation for a future career in science.
This module provides training in research methods in molecular biology, in an industrial lab, by means of an extended project. Training is also provided in record keeping and writing up. Projects are supervised by industrial research staff, in liaison with a member of MBB staff: this will include a site visit. This unit is deed to provide students with experience of undertaking investigations independently on a specific research topic, in an industrial setting. The content of our courses is reviewed annually to make sure it's up-to-date and relevant.
Individual modules are occasionally updated or withdrawn. This is in response to discoveries through our world-leading research; funding changes; professional accreditation requirements; student or employer feedback; outcomes of reviews; and variations in staff or student s. In the event of any change we'll consult and inform students in good time and take reasonable steps to minimise disruption. We are no longer offering unrestricted module choice. If your course included unrestricted modules, your department will provide a list of modules from their own and other subject areas that you can choose from.
Our research-embedded teaching comes from the forefront of molecular biology and across the breadth of bioscience. This breadth of expertise means we can offer a wide range of modules for you to choose from across the molecular biosciences, biomedicine, and organisms and the environment. We invest to create the right environment for you.Sheffield man needed for dd type of relationship
email: [email protected] - phone:(967) 437-8709 x 5010
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